1 Binding mode of the activity - modulating C - terminal segment of NS 2 B to NS 3 in the dengue virus NS 2 B - NS 3 protease

TITLE : Novel Dengue Virus - Specific NS 2 B / NS 3 Protease Inhibitor , BP 2109 , Discovered by a 1 High - Throughput Screening Assay

Molecular and Phylogenetic Analysis and Protein Structural modeling of NS Gene of Human Influenza A Virus Subtype H1N1 Circulating in Iran 2015 & 2017

Abstract Background:   The NS (non-structural) genomic segment of influenza A virus expresses two proteins (NS1 and NS2) which are responsible for the virulence and pathogenicity of virus. In this study we investigate the characterization and variability of the NS gene recovered from H1N1 influenza viruses isolated from Iranian patients during the 2017 seasonal outbreak  and from high...

Targeting Dengue Virus NS-3 Helicase by Ligand based Pharmacophore Modeling and Structure based Virtual Screening

Dengue fever is an emerging public health concern, with several million viral infections occur annually, for which no effective therapy currently exist. Non-structural protein 3 (NS-3) Helicase encoded by the dengue virus (DENV) is considered as a potential drug target to design new and effective drugs against dengue. Helicase is involved in unwinding of dengue RNA. This study was conducted to ...

Scanning Mutagenesis Studies Reveal Potential Intramolecular Interaction within the 1 C - terminal Half of Dengue Virus NS 2 A Involved in Viral RNA Replication and Virus 2 Assembly / Secretion 3 4

Sequence Analysis and Phylogenetic Profiling of the Nonstructural (NS) Genes of H9N2 Influenza A Viruses Isolated in Iran during 1998-2007

The earliest evidences on circulation of Avian Influenza (AI) virus on the Iranian poultry farms date back to 1998. Great economic losses through dramatic drop in egg production and high mortality rates are characteristically attributed to H9N2 AI virus. In the present work non-structural (NS) genes of 10 Iranian H9N2 chicken AI viruses collected during 1998-2007 were fully sequenced and subjec...